The Miocene Kavala granodiorite in northern Greece was emplaced into metamorphic rocks of the Rhodope Massif. A system of mineralized, sheeted quartz-sericite-feldspar veins crosscut the magmatic rock. The ore minerals include pyrite, tetradymite, bismuthinite, cosalite and Sb-lillianite. Two fluid inclusion types were found: CO2-H2O (Th=303-328oC) and H2O-NaCl- CaCl2 inclusions (Th=285-419oC, with a peak at 370oC). The co-existence of two types of fluid inclusions reveal that two immiscible fluids were present during entrapment: a H2O-NaCl-CO2 fluid with low salinity (5.9-6.8 wt% NaCl equiv.) and a moderate salinity (17-22 wt% NaCl equiv.) aqueous solution containing H2O-NaCl-CaCl2.